Modulation of IL-6 in ameliorating arthritic conditions in rats by Rosa alba L flower extract and fraction

Introduction: rheumatoid arthritis characterized by joint inflammation and pain,affecting millions of peoples around the world. Traditional system medicine hadproven to be preventive treating physical mental illness. Objective: theobjective study is assess anti-arthritic potential plant Rosa alba L byconsidering CFA, formaldehyde turpentine oil induced arthritic model. Materialand Method: ethanolic extract its ethyl acetate fraction were considered for thestudy quercetin was quantitatively estimated high performance thin layer chromatographic(HPTLC) method. Moreover, hematological biochemical studies(IL-6) performed in blood serum wistar albino rat. Then histopathologicalstudies had also been on rat hind paw joint. Result: phytochemicalscreening presence carbohydrates, phenolic compounds, flavonoids,phytosterols, amino acids fixed ofthe plant. Amount flowers found 0.26% w/wby quantitative HPTLC The level proinflammatory cytokines, interleukin(IL-6) considerably decreased (p<0.001) treated group rats at400 mg/kg b.w considering complete freund’s adjuvant (CFA) Conclusion: Ameliorated hematological,hematological, histopathologicalparameters confirmed antiarthritic